Ketamine: an update on the first twenty-five years of clinical experience

  title={Ketamine: an update on the first twenty-five years of clinical experience},
  author={David L. Reich and George Silvay},
  journal={Canadian Journal of Anaesthesia},
RésuméPendant presque 25 ans ďexpérience clinique, les bénéfices et les limitations de ľanesthésie à la kétamine ont été généralement bien définis. Les revues extensives de White et al.2 ainsi que celles de Reeves et al.43 ont énormément aidé à comprendre ľanesthésie dissociative. Néanmoins, des études récentes continuent à nous éclairer sur les différents aspects de la pharmacologie de la kétamine et suggèrent de nouvelles utilisations cliniques de cette drogue. Ľidentification du récepteur du… 
Estudio de toxicidad aguda S(+)-Ketamina y RS-Ketamina administrada por vía subaracnoidea en conejos. Comparación con lidocaína.
Hay publicados numerosos estudios sobre la ketamina administrada por via subaracnoidea en animales de experimentacion y en humanos, sin embargo los datos sobre la neurotoxicidad que produce son
La ketamina mejora la supervivencia en ratas con quemaduras severas vía la expresión de la proteína de choque térmico 70, ¿cerca o lejos de la perspectiva clínica?
The purpose of this reflection or commentary is not to demerit the efforts of the researchers, but rather to highlight some aspects that should be taken into account in the future for implementing
Anestesia total intravenosa (ATI) para herniorrafias umbilicais em bezerros
Se llego a the conclusion of that the tecnica anestesica empleada promovio depresion respiratoria, aumento de glicemia y periodo prolongado ofrecido de recuperacion anesteica en vacunos arena.
Einsatz von Ketamin bei Sepsis und systemischen Entzündungsreaktionen
Ketamine appears to represent a beneficial therapeutic option for long-term sedation of patients with arterial hypotension resulting from sepsis and systemic inflammatory response syndrome (SIRS), however, it has to be taken into account that ketamine inhibits endothelial nitric oxide synthase, thereby potentially aggravating impaired (micro) regional blood flow in sepsi.
Encefalitis rábica humana por mordedura de murciélago en un área urbana de Colombia
Se presenta el caso de un adolescente con encefalitis rabica adquirida cuatro meses despues de ser mordido por un murcielago en el area urbana de Floridablanca (Santander), Colombia. La complejidad
History of anaesthesia : the k etamine story – past , present and future
O Ketamine’s history begins in the 1950s in Detroit, Michigan, at Parke-Davis Laboratories. On 26 March 1956, Harold V. Maddox synthesised phencyclidine or PCP. Domino studied PCP effects in animals
Ketamine: Its Safety, Tolerability, and Impact on Neurocognition
The issues of ketamine’s safety, tolerability, and effects on neurocognition when used as anesthesia for electroconvulsive therapy are discussed.


A randomized evaluation of the reversal of ketamine by physostigmine
The results demonstrate that physostigmine does not shorten recovery time or reduce the occurrence of ketamine emergence phenomena such as hallucinations, restlessness and dreams, and suggest some synergism between the effects of ketamines and physostigsmine and should discourage the use of physostIGmine as a ketamine antidote.
A comparison of the effects of continuous ketamine infusion and halothane on oxygenation during one-lung anaesthesia in dogs
SummaryIt has been shown that a continuous infusion of ketamine during one-lung anaesthesia combined with a 50 per cent oxygen-curare anaesthetic technique will provide consistently lower shunt
Antagonism of ketamine by 4-aminopyridine and physostigmine.
The paper by Agoston and others (1980) demonstrating the ability of 4-aminopyridine to enhance the rate of recovery from ketamine—diazepam anaesthesia in humans is read with interest.
Kétamine par voie rectale pour l'induction de l'anesthésie pédiatrique
Children aged 6 months to 3 years old with congenital heart disease, and mentally retarded 14 to 18 years old affected by pneumopathia received 10 mg kg-1 ketamine by rectal administration and induction was smooth and well tolerated.
Pharmacology of Ketamine Isomers in Surgical Patients
Differences in anesthetic potencies, intraoperative effects, analgesia, physical side effects, incidences and types of postanesthetic emergence phenomena, and anesthetic preferences among the optical isomers of ketamine are disclosed.
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate
The results suggest that reduction of synaptic excitation mediated via NMA receptors contributes to the anaesthetic/analgesic properties of these two dissociative anaesthetics.
Ketamine kinetics in unmedicated and diazepam‐premedicated subjects
Diazepam‐ketamine treatment resulted in higher plasma levels at most time points, but diazepam pretreatment did not alter plasma levels of metabolite KI and pseudometabolite KII nor the 24‐hr urinary excretion of ketamine, KI, and KII.
Comparative Evaluation of Intravenous Agents for Rapid Sequence Induction—Thiopental, Ketamine, and Midazolam
Midazolam effectively attenuated both the cardiostimulatory responses and unpleasant emergence reactions associated with ketamine in patients undergoing emergency surgery, which may offer an advantage over thiopental in situations where hemodynamic stability is crucial.
Comparison of Ketamine and Thiopental in Healthy Volunteers: Effects on Mental Status, Mood, and Personality
There was a significantly greater incidence of abnormalities of mental status in subjects given ketamine than in those who had received thiopental after anesthesia, and no significant differences were found with regard to long-term changes in personality.
Glycopyrrolate during ketamine/diazepam anaesthesia A double‐blind comparison with atropine
There were no statistically significant differences with respect to salivation, blood pressure, heart rate, nausea and/or vomiting, unpleasant dreams and arousal time during induction of anaesthesia with ketamine and diazepam for alloplastic hip or knee surgery.