Ketamine: a versatile tool for anesthesia and analgesia.

  title={Ketamine: a versatile tool for anesthesia and analgesia.},
  author={William Barrett and Michael Buxhoeveden and Sabrina K. Dhillon},
  journal={Current Opinion in Anaesthesiology},
PURPOSE OF REVIEW Ketamine has been used for decades for a variety of indications. Beyond the historical benefits and effects of ketamine, newer developments have occurred worthy of an update. This review will discuss common uses and indications for ketamine in the perioperative setting, as well as highlight newer indications in recent years. RECENT FINDINGS Multiple studies have examined the use of ketamine in a variety of environments, as ketamine has become more popular in emergency rooms… Expand
5 Citations
Efficacy of opioids and non-opioid analgesics in the treatment of post procedure pain of burned patients: a narrative review.
Fentanyl, nalbuphine, and ketamine seem to be effective for controlling acute pain in burn patients, whereas gabapentin and lidocaine did not show any efficacy. Expand
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More precise PK/PD models may improve the ketamine use regimen and the findings from research on depression are an important discovery because ketamine's impact on neuronal plasticity and synaptogenesis in human brain disease has directly been documented. Expand
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Ketamine is a potent proapoptotic drug that has original antiproinflammatory properties and is highly effective against surgery and opiate-induced hyperalgesia, but has not yet revealed all its interactions in humans. Expand
Ketamine—A Narrative Review of Its Uses in Medicine
This review will serve to touch on ketamine's chemical data, pharmacokinetics and pharmacodynamics, medical uses, and adverse effects while focusing specifically on the drugs usage in anesthesia and analgesia. Expand
Perioperative ketamine for acute analgesia and beyond
  • S. Porter
  • Medicine
  • Romanian journal of anaesthesia and intensive care
  • 2019
The history of ketamine’s clinical use; basic ketamine pharmacology; evidence for the use of perioperative ketamine for analgesia; comments on patient selection for ketamine research; a discussion of the safety and side effect profile of ketamines infusions beyond the operating room; and ketamine as a treatment option for psychiatric diseases. Expand
Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review
In a number of limited situations, ketamine has shown some efficacy in controlling postoperative pain and decreasing opioid consumption, but these effects are dose-dependent. Expand
Ketamine Use in the Intensive Care Unit
Practical considerations for use of ketamine in the intensive care unit (ICU) are reviewed, as are its most common uses, including as an analgesic and during RSI and procedural sedation. Expand
Update on the Physiologic Effects of Ketamine in General Anesthesia and Spinal Blockade: A Review of the Literature.
The primary scientific literature is reviewed and recent studies that have implicated ketamine in inflammation and oxidative stress, inhibition of ion channels in dorsal horn neurons, and in disruption of frontoparietal communication are discussed. Expand
A systematic review of intravenous ketamine for postoperative analgesia
Intravenous ketamine is an effective adjunct for postoperative analgesia, and particular benefit was observed in painful procedures, including upper abdominal, thoracic, and major orthopedic surgeries. Expand
Ketamine: Current applications in anesthesia, pain, and critical care
The present article attempts to review the current useful applications of ketamine in anesthesia, pain and critical care based on scientific evidence gathered from textbooks, journals, and electronic databases. Expand
Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug
Reevaluation, though, of analgesic properties of ketamine resulted in new interest regarding its use in perioperative and chronic pain management and recent studies in the effects of the substance on intracranial pressure and cerebral blood flow led to revising the recommendation against itsUse in brain injury. Expand
Wherefore ketamine?
  • J. Persson
  • Medicine
  • Current opinion in anaesthesiology
  • 2010
Purpose of review Ketamine has been repeatedly reviewed in this journal but novel developments have occurred in the last few years prompting an update. Interesting recent publications will beExpand