Ketamine: Teaching an Old Drug New Tricks

@article{Kohrs1998KetamineTA,
  title={Ketamine: Teaching an Old Drug New Tricks},
  author={R. Kohrs and M. Durieux},
  journal={Anesthesia & Analgesia},
  year={1998},
  volume={87},
  pages={1186-1193.}
}
  • R. Kohrs, M. Durieux
  • Published 1998
  • Medicine
  • Anesthesia & Analgesia
  • K etamine has a special position among anesthetic drugs. It was introduced into clinical practice >30 yr ago with the hope that it would function as a “monoanesthetic” drug: inducing analgesia, amnesia, loss of consciousness, and immobility. This dream was not fulfilled because significant side effects were soon reported. With the introduction of other IV anesthetic drugs, ketamine’s role diminished rapidly. However, it is still used clinically for indications such as induction of anesthesia in… CONTINUE READING
    623 Citations

    Paper Mentions

    Interventional Clinical Trial
    The purpose of this study is to determine if the use of ketamine, sniffed in the nose, is a safe and effective way to help reduce pain in pediatric sickle cell patients with pain crises… Expand
    ConditionsSickle Cell Disease
    InterventionDrug, Other
    Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug
    • 125
    • PDF
    Ketamine applications beyond anesthesia - A literature review.
    • 7
    Ketamine: a new look at an old drug.
    • 65
    Ketamine and kids: an update
    • 79
    • PDF
    General anesthesia in cardiac surgery: a review of drugs and practices.
    • 10
    • Highly Influenced
    • PDF
    The use of ketamine or ketamine-midazolam for adenotonsillectomy.
    • 13

    References

    SHOWING 1-10 OF 93 REFERENCES
    Ketamine: a review of its pharmacologic properties and use in ambulatory anesthesia.
    • 171
    Pharmacology of Ketamine Isomers in Surgical Patients
    • 355
    Ketamine Potentiates Analgesic Effect of Morphine in Postoperative Epidural Pain Control
    • 116
    [Clinical significance of S-(+)-ketamine].
    • 8
    Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia.
    • 278
    Preemptive Ketamine Decreases Postoperative Narcotic Requirements in Patients Undergoing Abdominal Surgery
    • 213
    • Highly Influential
    Intervention with spinal NMDA, adenosine, and NO systems for pain modulation.
    • 53