Ketamine, an NMDA-antagonist, increases the oscillatory frequencies of alpha-peaks on the electroencephalographic power spectrum.

@article{Tsuda2007KetamineAN,
  title={Ketamine, an NMDA-antagonist, increases the oscillatory frequencies of alpha-peaks on the electroencephalographic power spectrum.},
  author={Naoki Tsuda and Kazuko Hayashi and Satoshi Hagihira and Teiji Sawa},
  journal={Acta anaesthesiologica Scandinavica},
  year={2007},
  volume={51 4},
  pages={472-81}
}
BACKGROUND Ketamine, an N-methyl-D-aspartate (NMDA) antagonist, is known to activate the electroencephalogram (EEG), despite its sedative effects. Spindle oscillations are known to be related to the sedative actions of the reticular thalamic nucleus with links to thalamocortical neurons. This study was designed to examine the effect of ketamine on the spindle oscillations to understand the simultaneous sedative effect and EEG activation that occurs with ketamine, by comparing the EEG in… CONTINUE READING
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