Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions

@inproceedings{Bojak2013KetaminePA,
  title={Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions},
  author={Ingo Bojak and Harry C. Day and David T. J. Liley},
  booktitle={Front. Comput. Neurosci.},
  year={2013}
}
Ketamine and propofol are two well-known, powerful anesthetic agents, yet at first sight this appears to be their only commonality. Ketamine is a dissociative anesthetic agent, whose main mechanism of action is considered to be N-methyl-d-aspartate (NMDA) antagonism; whereas propofol is a general anesthetic agent, which is assumed to primarily potentiate currents gated by γ-aminobutyric acid type A (GABAA) receptors. However, several experimental observations suggest a closer relationship… CONTINUE READING