Keratolenticular dysgenesis (Peters' anomaly) as a result of acute embryonic insult during gastrulation.

@article{Cook1988KeratolenticularD,
  title={Keratolenticular dysgenesis (Peters' anomaly) as a result of acute embryonic insult during gastrulation.},
  author={Cynthia S Cook and Kathleen K. Sulik},
  journal={Journal of pediatric ophthalmology and strabismus},
  year={1988},
  volume={25 2},
  pages={
          60-6
        }
}
Keratolenticular dysgenesis (Peters' anomaly) was induced in mice by exposure to the human teratogens, ethanol or 13-cis retinoic acid (isotretinoin, Accutane). Acute teratogen exposure on the seventh day of gestation (corresponding to the third week of human gestation) resulted in an eye malformation incidence of 46% to 100% in day 14 fetuses. Of the abnormal eyes, 10% to 29% demonstrated failure of detachment of the lens from the surface ectoderm. Delayed lens detachment was seen as anterior… CONTINUE READING
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