Keratins modulate colonocyte electrolyte transport via protein mistargeting

@article{Toivola2004KeratinsMC,
  title={Keratins modulate colonocyte electrolyte transport via protein mistargeting},
  author={D. Toivola and S. Krishnan and H. Binder and S. Singh and M. Omary},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={911 - 921}
}
The function of intestinal keratins is unknown, although keratin 8 (K8)–null mice develop colitis, hyperplasia, diarrhea, and mistarget jejunal apical markers. We quantified the diarrhea in K8-null stool and examined its physiologic basis. Isolated crypt-units from K8-null and wild-type mice have similar viability. K8-null distal colon has normal tight junction permeability and paracellular transport but shows decreased short circuit current and net Na absorption associated with net Cl… Expand
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