Keratins in health and cancer: more than mere epithelial cell markers

@article{Karantza2011KeratinsIH,
  title={Keratins in health and cancer: more than mere epithelial cell markers},
  author={Vassiliki Karantza},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={127-138}
}
Keratins are the intermediate filament (IF)-forming proteins of epithelial cells. Since their initial characterization almost 30 years ago, the total number of mammalian keratins has increased to 54, including 28 type I and 26 type II keratins. Keratins are obligate heteropolymers and, similarly to other IFs, they contain a dimeric central α-helical rod domain that is flanked by non-helical head and tail domains. The 10-nm keratin filaments participate in the formation of a proteinaceous… CONTINUE READING

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