Keratinocytes in inflammatory skin diseases.

@article{Albanesi2005KeratinocytesII,
  title={Keratinocytes in inflammatory skin diseases.},
  author={Cristina Albanesi and Claudia Scarponi and Maria Laura Giustizieri and Giampiero Girolomoni},
  journal={Current drug targets. Inflammation and allergy},
  year={2005},
  volume={4 3},
  pages={329-34}
}
Although in the past, keratinocytes were considered simply as passive targets of immunological attack from infiltrating T lymphocytes, a number of studies have definitively demonstrated that keratinocytes actively participate in the cutaneous immune responses. Upon activation, keratinocytes express a plethora of cytokines, chemokines and accessory molecules, which can transmit both positive and negative signals to cells of innate and adaptive immunity. Dysregulation and abnormal expression of… CONTINUE READING

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