Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.

@article{Suzuki2003KeratinocytespecificPD,
  title={Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.},
  author={Akira John Suzuki and Satoshi Itami and Minako Ohishi and Koichi Hamada and Tae Inoue and Nobuyasu Komazawa and Haruki Senoo and Takehiko Sasaki and J. Takahashi Takeda and Motomu Manabe and Tak W Mak and Toru Nakano},
  journal={Cancer research},
  year={2003},
  volume={63 3},
  pages={674-81}
}
PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice (k5Pten(flox/flox) mice). k5Pten(flox/flox) mice exhibit wrinkled skin because of epidermal hyperplasia and hyperkeratosis and ruffled, shaggy, and curly hair. Histological examination revealed that skin morphogenesis is accelerated in k5Pten(flox/flox) mice. Within 3 weeks of birth, 90% of k5Pten(flox/flox) mice die of malnutrition… CONTINUE READING
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