Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents

@article{Braun2006KeratinocyteGF,
  title={Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents},
  author={Susanne Braun and Monika Krampert and Enikő Bod{\'o} and Angelika K{\"u}min and Christiane Born-Berclaz and Ralf Paus and Sabine Werner},
  journal={Journal of Cell Science},
  year={2006},
  volume={119},
  pages={4841 - 4849}
}
Owing to its potent cytoprotective properties for epithelial cells, keratinocyte growth factor (KGF) is successfully used for the treatment of chemotherapy- and radiotherapy-induced oral mucositis in cancer patients. It is therefore of major interest to determine possible clinical applications of KGF in other organs and in different stress situations and to unravel common and organ-specific mechanisms of KGF action. Here we show that KGF protects human keratinocytes from the toxicity of… 
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References

SHOWING 1-10 OF 79 REFERENCES

Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.

Rec recombinant human KGF used as a pretreatment in several mouse models of chemotherapy and/or radiation-induced gastrointestinal injury significantly improved mouse survival and indicates that KGF may be therapeutically useful to lessen the intestinal side effects of current cancer therapy regimens.

UVB-induced activation and internalization of keratinocyte growth factor receptor

Results demonstrate that exposure to UVB and to oxidant stimuli induces a rapid intracellular production of ROS, which in turn are capable of triggering KGFR activation and internalization, similar to those induced by KGF.

Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair.

Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor.

KGF may be of clinical value in reducing radiation toxicity to the intestine and treatment with both KGF and stem cell factor increased the number of surviving crypt cells after irradiation to levels similar to that in animals treated with KGF alone.

Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2exposure.

The ability of KGF to protect against oxidant-induced lung injury is partly due to enhanced AEC DNA repair, and it is concluded that KGF attenuates H2O2-induced DNA-SB formation in cultured AECs by mechanisms that involve tyrosine kinase, PKC, and DNA polymerases.

The effects of keratinocyte growth factor in preclinical models of mucositis

KGF may be useful for the prevention or treatment of mucositis in patients treated with regimens of cancer therapy that have gastrointestinal toxicity, preliminary studies suggest.

Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

Rec recombinant KGF induced dose-dependent hair growth over most of the body in nu/nu athymic nude mice when administered intraperitoneally or subcutaneously over 17 to 18 days, and induced the most extensive hair growth at the sites of injection.

EGF-R dependent regulation of keratinocyte survival.

Evidence linking epidermal growth factor-receptor activation to survival of normal human keratinocytes in culture is described, indicating that adhesion-dependent and EGF-R-dependent signal transduction pathways serve partially overlapping but not redundant roles in supporting keratinocyte survival.

Endocytic pathways and biological effects induced by UVB‐dependent or ligand‐dependent activation of the keratinocyte growth factor receptor

  • F. BelleudiL. Leone M. Torrisi
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
A differential role of KGFR and EGFR in the response of epidermal cells to UVB possibly because KG FR endocytosis could be crucial for attenuation of survival signals in the suprabasal layers of human skin is suggested.

Novel roles of NM23 proteins in skin homeostasis, repair and disease

Findings suggest that epidermal homeostasis depends on a tight regulation of the levels of NM23 isoforms, which are involved in the regulation of many cellular processes as well as in tumor metastasis.
...