Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool.

@article{Lombaert2008KeratinocyteGF,
  title={Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool.},
  author={Isabelle M. A. Lombaert and Jeanette F. Brunsting and Pieter Klaas Wierenga and Harm H. Kampinga and Gerald de Haan and Rob P Coppes},
  journal={Stem cells},
  year={2008},
  volume={26 10},
  pages={2595-601}
}
Irradiation of salivary glands during radiotherapy treatment of patients with head and neck cancer evokes persistent hyposalivation. This results from depletion of stem cells, which renders the gland incapable of replenishing saliva to produce acinar cells. The aim of this study was to investigate whether it is possible to expand the salivary gland stem/progenitor cell population, thereby preventing acinar cell depletion and subsequent gland dysfunction after irradiation. To induce cell… CONTINUE READING