Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.

@article{Rossi2002KeratinocyteGF,
  title={Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.},
  author={Simona Rossi and Bruce R Blazar and Catherine L. Farrell and Dimitry M. Danilenko and David L. Lacey and Kenneth I. Weinberg and Werner Krenger and Georg A. Hollaender},
  journal={Blood},
  year={2002},
  volume={100 2},
  pages={682-91}
}
Thymus-dependent reconstitution of the peripheral T-cell compartment is critical for the successful outcome of bone marrow transplantation. However, graft-versus-host disease (GVHD) affects thymic stromal function and thus prevents normal T-cell maturation and selection. To determine whether cytoprotection of thymic epithelial cells (TECs) by keratinocyte growth factor (KGF) averts GVHD-related injury to the thymus, a nonirradiated murine parent-->F(1) transplantation model was investigated… CONTINUE READING

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