Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.

@article{Chandel2009KeratinocyteGF,
  title={Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.},
  author={Navdeep S Chandel and G. R. Scott Budinger and G{\"o}khan M Mutlu and John Varga and Lauren Synenki and Helen K. Donnelly and Aaron Zirk and James Eisenbart and Borko Jovanovic and Manu Jain},
  journal={Critical care medicine},
  year={2009},
  volume={37 5},
  pages={1678-84}
}
OBJECTIVE Keratinocyte growth factor (KGF) is expressed primarily by fibroblasts, is important for alveolar epithelial proliferation/function, and protects against lung injury in multiple animal models. We wished to determine whether acute lung injury/acute respiratory distress syndrome (ALI/ARDS) alveolar fluid induces KGF and fibroblast genes important for alveolar repair. DESIGN A single-center cohort study enrolling patients between 2004 and 2006. SETTING A medical intensive care unit… CONTINUE READING

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Keratinocyte growth factor expression is suppressed in early acute lung injury / acute respiratory distress syndrome by smad and c - Abl pathways . OBJECTIVE .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
Keratinocyte growth factor expression is suppressed in early acute lung injury / acute respiratory distress syndrome by smad and c - Abl pathways . OBJECTIVE .
Fifteen patients with ALI / ARDS , five patients with cardiogenic edema , and five normal lung parenchyma controls were enrolled from 2004 to 2006 .
Fifteen patients with ALI / ARDS , five patients with cardiogenic edema , and five normal lung parenchyma controls were enrolled from 2004 to 2006 .
Fifteen patients with ALI / ARDS , five patients with cardiogenic edema , and five normal lung parenchyma controls were enrolled from 2004 to 2006 .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
Keratinocyte growth factor expression is suppressed in early acute lung injury / acute respiratory distress syndrome by smad and c - Abl pathways . OBJECTIVE .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
Keratinocyte growth factor expression is suppressed in early acute lung injury / acute respiratory distress syndrome by smad and c - Abl pathways . OBJECTIVE .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
Fifteen patients with ALI / ARDS , five patients with cardiogenic edema , and five normal lung parenchyma controls were enrolled from 2004 to 2006 .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
Keratinocyte growth factor expression is suppressed in early acute lung injury / acute respiratory distress syndrome by smad and c - Abl pathways . OBJECTIVE .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
We wished to determine whether acute lung injury / acute respiratory distress syndrome ( ALI / ARDS ) alveolar fluid induces KGF and fibroblast genes important for alveolar repair .
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