Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate.

@article{Sugimura1996KeratinocyteGF,
  title={Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate.},
  author={Yoshiki Sugimura and Barbara A. Foster and Yun Kit Hom and Joshua H. Lipschutz and Jeffrey S. Rubin and Paul W. Finch and Stuart A. Aaronson and Nobukazu Hayashi and Juichi Kawamura and Gerald R. Cunha},
  journal={The International journal of developmental biology},
  year={1996},
  volume={40 5},
  pages={941-51}
}
Prostatic growth occurs through ductal elongation and branching into the mesenchyme. Ductal branching morphogenesis in the prostate is elicited by androgens via mesenchymal-epithelial interactions mediated by paracrine influences from mesenchyme. The role of keratinocyte growth factor (KGF) was investigated in the developing prostate as KGF has been suggested to be a paracrine acting factor. KGF transcripts were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in neonatal… CONTINUE READING