Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin.

@article{Meng1998KeratinocyteGT,
  title={Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin.},
  author={Xianmin Meng and Daisuke Sawamura and Katsuto Tamai and Katsumi Hanada and Hirotomo Ishida and Isao Hashimoto},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 6},
  pages={1462-7}
}
This study has examined the systemic effects of a circulating gene product, human interleukin 10 (IL-10), released from transduced keratinocytes. IL-10 is an anti-inflammatory cytokine which has an inhibitory effect on contact hypersensitivity (CHS). An expression vector (phIL-10) was constructed for human IL-10 and was injected into the dorsal skin of hairless rats. Local expression of IL-10 mRNA and protein was detected by reverse-transcriptase polymerase chain reaction and… CONTINUE READING

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