Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage.

@article{Frink2007KeratinocytederivedCP,
  title={Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage.},
  author={Michael Frink and Ya-Ching M Hsieh and Chi-Hsun Hsieh and H. -Ch. Pape and Mashkoor A. Choudhry and Martin G. Schwacha and Irshad H. Chaudry},
  journal={Shock},
  year={2007},
  volume={28 5},
  pages={576-81}
}
Neutrophil infiltration is a crucial step in the development of organ dysfunction after trauma. We have previously shown that keratinocyte-derived chemokine (KC), a chemoattractant for neutrophils, is up-regulated after trauma-hemorrhage. To determine the role of KC after trauma-hemorrhage, the effect of a KC-neutralizing antibody on the posttraumatic inflammatory response was examined. One hour before surgery, male C3H/HeN mice were treated with an anti-KC antibody or isotype control. Animals… CONTINUE READING