Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice

@inproceedings{AdairKirk2012KeratinocyteTargetedEO,
  title={Keratinocyte-Targeted Expression of Human Laminin γ2 Rescues Skin Blistering and Early Lethality of Laminin γ2 Deficient Mice},
  author={Tracy L. Adair-Kirk and Gail L. Griffin and M. J. Meyer and Diane G. Kelley and Jeffrey H Miner and Douglas R. Keene and Matt Peter Marinkovich and John Michael Ruppert and Jouni Uitto and Robert M. Senior},
  booktitle={PloS one},
  year={2012}
}
Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and adult tissues. In skin, laminin-332 is secreted by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the underlying dermis. In mice, lack of expression of any of the three Laminin-332 chains result in impaired… CONTINUE READING

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