Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps

  title={Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps},
  author={Toshio Ishibashi and Tadashi Tanaka and Shin-ichi Ishimoto and Ken‐ichi Nibu and Kimitaka Kaga},
  journal={Annals of Otology, Rhinology \& Laryngology},
  pages={885 - 890}
To examine the potential biologic role of fibroblast growth factors (FGFs) in nasal polyps and nasal mucosa during chronic inflammatory conditions, we investigated messenger RNA (mRNA) expression of three members of the FGF family — Acidic FGF, basic FGF, and keratinocyte growth factor (KGF) — in nasal polyp tissues, as well as in hyperplastic nasal mucosa. Using the sensitive method reverse transcription-polymerase chain reaction (RT-PCR), we demonstrated that of the examined FGFs, KGF had the… 

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