Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps

@article{Ishibashi1998KeratinocyteGF,
  title={Keratinocyte Growth Factor and its Receptor Messenger RNA Expression in Nasal Mucosa and Nasal Polyps},
  author={Toshio Ishibashi and Tadashi Tanaka and Shin-ichi Ishimoto and Ken‐ichi Nibu and Kimitaka Kaga},
  journal={Annals of Otology, Rhinology \& Laryngology},
  year={1998},
  volume={107},
  pages={885 - 890}
}
To examine the potential biologic role of fibroblast growth factors (FGFs) in nasal polyps and nasal mucosa during chronic inflammatory conditions, we investigated messenger RNA (mRNA) expression of three members of the FGF family — Acidic FGF, basic FGF, and keratinocyte growth factor (KGF) — in nasal polyp tissues, as well as in hyperplastic nasal mucosa. Using the sensitive method reverse transcription-polymerase chain reaction (RT-PCR), we demonstrated that of the examined FGFs, KGF had the… 

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References

SHOWING 1-10 OF 16 REFERENCES
Large induction of keratinocyte growth factor expression in the dermis during wound healing.
TLDR
The results suggest that basal keratinocytes are stimulated by dermally derived KGF during wound healing and implicate a unique role of this member of the FGF family in wound repair.
Regulation of keratinocyte growth factor gene expression by interleukin 1.
TLDR
The stimulation of KGF expression by IL1 and other cytokines such as IL6, transforming growth factor alpha, and platelet-derived growth factor may provide a mechanism for KGF induction during inflammation that would support its proposed role as mediator of reepithelialization and wound healing.
Keratinocyte growth factor and fibroblast growth factor action on DNA synthesis in rat and human hepatocytes: modulation by heparin.
TLDR
Testing the activity of KGF on normal adult rat and human hepatocytes and their modulation by heparin indicates that KGF is capable of acting as a complete mitogen for rat hepatocytes in culture and that the activity is consistent with expression by these cells of a type II FGF receptor subtype, the KGF receptor.
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
TLDR
Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.
The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells.
TLDR
The presence of mRNA for aF GF, a potent endothelial and smooth muscle cell mitogen, in allograft myocardium suggests that aFGF may play a role in the pathogenesis of CAV.
Purification and characterization of a newly identified growth factor specific for epithelial cells.
TLDR
The release of this growth factor by human embryonic fibroblasts raises the possibility that KGF may play a role in mesenchymal stimulation of normal epithelial cell proliferation, and Lack of mitogenic activity on either fibro Blasts or endothelial cells indicated that K GF possessed a target cell specificity distinct from any previously characterized growth factor.
Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor.
TLDR
The KGF and KGF receptor genes are expressed in rat mammary glands and recombinant KGF is a potent growth factor for mammary epithelium.
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.
TLDR
Two growth factor receptors with different ligand-binding specificities and expression patterns are encoded by alternative transcripts of the same gene, as revealed by cDNA cloning and structural analysis of the KGFR.
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.
TLDR
An expression cloning strategy was devised to isolate the keratinocyte growth factor (KGF) receptor complementary DNA, which indicated that this receptor had high affinity for acidic FGF as well as KGF.
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
TLDR
The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family, and the KGF transcript was present in stromal cells derived from epithelial tissues.
...
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