Keratinocyte Growth Factor (KGF) in hematology and oncology.

  title={Keratinocyte Growth Factor (KGF) in hematology and oncology.},
  author={Kelli P A Macdonald and Geoffrey R Hill},
  journal={Current pharmaceutical design},
  volume={8 5},
Keratinocyte Growth factor (KGF) is an epithelial cell growth factor of the fibroblast growth factor family and is produced by fibroblasts and microvascular endothelium in response to proinflammatory cytokines and steroid hormones. KGF is a heparin binding growth factor that exerts effects on epithelial cells in a paracrine fashion through interaction with KGF receptors. Preclinical data has demonstrated that KGF can prevent lung and gastrointestinal toxicity following chemotherapy and… CONTINUE READING

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