Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity

@article{Aaronson1991KeratinocyteGF,
  title={Keratinocyte Growth Factor: A Fibroblast Growth Factor Family Member with Unusual Target Cell Specificity},
  author={Stuart A Aaronson and Donald P. Bottaro and Toru Miki and Dina Ron and Paul W. Finch and Timothy P Fleming and J. Ahn and William G. Taylor and Jeffrey S. Rubin},
  journal={Annals of the New York Academy of Sciences},
  year={1991},
  volume={638}
}
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References

SHOWING 1-10 OF 58 REFERENCES
The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.
TLDR
Several experiments strongly suggested that FGF-5 is a growth factor with properties common to those of acidic and basic FGFs, and this oncogene is the fifth documented protein related to fibroblast growth factors (FGFs).
Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells
TLDR
The data suggest that heparin-binding growth factor 1-induced signal transduction involves, in part, the tyrosine phosphorylation of at least three polypeptides, which is consistent with the half-maximal concentration required for stimulation of DNA synthesis in NIH 3T3 cells.
Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture.
TLDR
Results indicate that keratin genes that are normally expressed in vivo in epidermis may be expressed in malignant epidermal cells under conditions that do not permit expression of these genes in nonmalignant primary epidersmal cells.
A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.
TLDR
A mouse receptor cloned with about 90% similarity to the chicken fibroblast growth factor (FGF) receptor and the human fms-like gene (FLG) tyrosine kinase can functionally interact with two growth factors of the FGF family.
Interactions of growth factors and retroviral oncogenes with mitogenic signal transduction pathways of Balb/MK keratinocytes.
TLDR
The findings establish the applicability of this system for biologic assay of epithelial cell growth factors as well as identification of specific growth factor requirements that can be altered or complemented by the actions of specific oncogenes.
Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography.
TLDR
Results confirm the existence of two distinct growth factors in bovine neural tissue and establish that the acidic endothelial cell growth factor from hypothalamus and the acidic brain fibroblast growth factor are identical.
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
TLDR
The demonstrating of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor shows that this protein could be a factor active transiently during normal cell growth.
Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain.
TLDR
Data indicate that ECGF is the principal mitogen for endothelial cells from bovine brain, that heparin affinity chromatography may be used to purify and concentrate ECGF, and that the affinity of ECGF forHeparin may have structural and perhaps biological significance.
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