Keratinocyte Differentiation Is Regulated by the Rho and ROCK Signaling Pathway

  title={Keratinocyte Differentiation Is Regulated by the Rho and ROCK Signaling Pathway},
  author={Rachel McMullan and Si{\^a}n Lax and Vicki H. Robertson and David Radford and Simon Broad and Fiona M Watt and Alison Rowles and Daniel R. Croft and Michael F Olson and Neil A Hotchin},
  journal={Current Biology},
The epidermis comprises multiple layers of specialized epithelial cells called keratinocytes. As cells are lost from the outermost epidermal layers, they are replaced through terminal differentiation, in which keratinocytes of the basal layer cease proliferating, migrate upwards, and eventually reach the outermost cornified layers. Normal homeostasis of the epidermis requires that the balance between proliferation and differentiation be tightly regulated. The GTP binding protein RhoA plays a… CONTINUE READING


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