Keratinocyte ATP release assay for testing skin-irritating potentials of structurally diverse chemicals.

@article{Mizumoto2003KeratinocyteAR,
  title={Keratinocyte ATP release assay for testing skin-irritating potentials of structurally diverse chemicals.},
  author={Norikatsu Mizumoto and Mark E. Mummert and David Shalhevet and Akira Takashima},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 5},
  pages={1066-72}
}
Irritant dermatitis represents innate inflammatory responses to toxic chemicals. We have reported recently that ATP released from chemically injured keratinocytes may serve as a causative mediator for irritant dermatitis. In this study, we examined whether ATP release from keratinocytes would serve as a reliable readout for predicting skin irritating potentials of structurally diverse compounds. A vast majority (19/20) of the tested compounds, i.e., strong and weak irritant chemicals selected… CONTINUE READING
30 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…