Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

@article{Strnad2010KeratinVP,
  title={Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.},
  author={Pavel Strnad and Qin Zhou and Shinichiro Hanada and Laura C Lazzeroni and Bi Hui Zhong and Phillip So and Timothy J. Davern and William M. Lee and M Bishr Omary},
  journal={Gastroenterology},
  year={2010},
  volume={139 3},
  pages={
          828-35, 835.e1-3
        }
}
BACKGROUND & AIMS Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in animal models, has not been studied in humans. METHODS We analyzed the entire coding regions of KRT8 and KRT18 genes (15 total exons and their exon-intron boundaries) to determine… CONTINUE READING

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