Keratin variants associate with progression of fibrosis during chronic hepatitis C infection.

@article{Strnad2006KeratinVA,
  title={Keratin variants associate with progression of fibrosis during chronic hepatitis C infection.},
  author={Pavel Strnad and Tim Christian Lienau and Guo-Zhong Tao and Laura C Lazzeroni and Felix Stickel and Detlef Schuppan and M Bishr Omary},
  journal={Hepatology},
  year={2006},
  volume={43 6},
  pages={
          1354-63
        }
}
Keratins 8 and 18 (K8/K18) protect the liver from various forms of injury. Studies of liver explants from a large cohort of U.S. patients showed that K8/K18 mutations confer a risk to developing end-stage liver diseases, though which diseases are preferentially involved is unknown. We tested the hypothesis that K8/K18 variants are associated with chronic hepatitis C (CHC) and that their presence correlates with progression of fibrosis. Genomic DNA was isolated from peripheral blood of a well… CONTINUE READING

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