Keratin intermediate filament expression in astrocytic neoplasms: analysis by immunocytochemistry, western blot, and northern hybridization.

@article{Cosgrove1993KeratinIF,
  title={Keratin intermediate filament expression in astrocytic neoplasms: analysis by immunocytochemistry, western blot, and northern hybridization.},
  author={M M Cosgrove and Kathryn A Rich and S A Kunin and Andy E. Sherrod and Sue Ellen Martin},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1993},
  volume={6 3},
  pages={342-7}
}
In this study, 29 formalin-fixed, paraffin-embedded astrocytic tumors were analyzed immunocytochemically with the antikeratin monoclonal antibodies Mak-6 and Cam 5.2 and a polyclonal antibody against glial fibrillary acidic protein (GFAP). Immunoreactivity for Mak-6 was present in 29 cases (100%) including six well-differentiated astrocytomas, nine anaplastic astrocytomas, and 14 glioblastomas multiforme. Cam 5.2 immunoreactivity was focally present in one case of GBM (4%) but was absent in the… CONTINUE READING

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