Keratin 8 mutations in patients with cryptogenic liver disease.

  title={Keratin 8 mutations in patients with cryptogenic liver disease.},
  author={N O Ku and Robert R Gish and Teresa Lyn Wright and M. Bishr Omary},
  journal={The New England journal of medicine},
  volume={344 21},
BACKGROUND About 10 percent of patients who undergo liver transplantation have cryptogenic liver disease. In animal models, the absence of heteropolymeric keratins 8 and 18 or the presence of mutant keratins in hepatocytes causes or promotes liver disease. We have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis, but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear. METHODS We tested for mutations in… CONTINUE READING
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