Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth

  title={Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth},
  author={N. Zhang and R. Zhang and K. Zou and Wendan Yu and W. Guo and Yingying Gao and J. Li and M. Li and Y. Tai and W. Huang and C. Song and W. Deng and X. Cui},
  journal={Cell Death & Disease},
  • N. Zhang, R. Zhang, +10 authors X. Cui
  • Published 2017
  • Biology, Medicine
  • Cell Death & Disease
  • The overexpression of human telomerase reverse transcriptase (hTERT) has been associated with the proliferation and migration of colorectal cancer (CRC) cells. We investigated the roles of KRT23 and hTERT in promoting CRC cell proliferation and migration. We verified the relationship between KRT23 and hTERT in CRC using streptavidin-agarose pulldown and chromatin immunoprecipitation (ChIP) assays. One hundred and fifty-four human CRC specimens were analyzed using immunohistochemistry. The roles… CONTINUE READING
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