Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.

@article{Yun2000Keratin2I,
  title={Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.},
  author={Kankatsu Yun and Arend E. H. Merrie and Jinny Gunn and L. V. Phillips and John L McCall},
  journal={The Journal of pathology},
  year={2000},
  volume={191 1},
  pages={
          21-6
        }
}
Lymph node status has major prognostic importance in colorectal cancer and greater precision in the diagnosis of lymph node metastases should provide better prognostic and therapeutic guidance. Keratin 20 (K20) gene expression has been used as a marker of lymph node metastases, but the evidence for this remains circumstantial. This study has therefore sought to determine K20 specificity and to correlate K20 expression with mutant K-RAS expression, in order to provide direct evidence that K20… CONTINUE READING

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Keratins in colorectal epithelial function and disease.

  • International journal of experimental pathology
  • 2012
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CITES BACKGROUND & METHODS
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Identification of occult tumor cells in node negative lymph nodes of colorectal cancer patients by cytokeratin 20 gene and protein expression

Silke Lassmann, M. Bauer, +5 authors Martin Werner
  • International Journal of Colorectal Disease
  • 2004
VIEW 1 EXCERPT
CITES BACKGROUND

Quantitative reverse transcription-polymerase chain reaction detection of cytokeratin 20 in noncolorectal lymph nodes.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2001