Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

@article{Depianto2010Keratin1P,
  title={Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin},
  author={Daryle Depianto and Michelle L Kerns and Andrzej A Dlugosz and Pierre A Coulombe},
  journal={Nature genetics},
  year={2010},
  volume={42},
  pages={910 - 914}
}
  • Daryle Depianto, Michelle L Kerns, +1 author Pierre A Coulombe
  • Published 2010
  • Biology, Medicine
  • Nature genetics
  • Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the case of BCC, an expanding set of genetic variants including keratin 5 (encoded by KRT5), an intermediate filament-forming protein. We here show that genetic ablation of keratin 17 (Krt17) protein, which is induced in basaloid skin tumors and co-polymerizes with Krt5 in vivo, delays basaloid follicular hamartoma tumor initiation and growth… CONTINUE READING

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