Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

@inproceedings{Depianto2010Keratin1P,
  title={Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin},
  author={Daryle Depianto and Michelle L Kerns and Andrzej A Dlugosz and Pierre A Coulombe},
  booktitle={Nature Genetics},
  year={2010}
}
Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the case of BCC, an expanding set of genetic variants including keratin 5 (encoded by KRT5), an intermediate filament-forming protein. We here show that genetic ablation of keratin 17 (Krt17) protein, which is induced in basaloid skin tumors and co-polymerizes with Krt5 in vivo, delays basaloid follicular hamartoma tumor initiation and growth… CONTINUE READING

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Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
Our findings establish an immunomodulatory role for Krt17 in Hh driven basaloid skin tumors that could impact additional tumor settings , psoriasis and wound repair .
Our findings establish an immunomodulatory role for Krt17 in Hh driven basaloid skin tumors that could impact additional tumor settings , psoriasis and wound repair .
Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
Basaloid skin tumors , including basal cell carcinoma ( BCC ) and basaloid follicular hamartoma , are associated with aberrant Hedgehog ( Hh ) signaling and , in the case of BCC , an expanding set of genetic variants including keratin 5 ( encoded by KRT5 ) , an intermediate filament - forming protein .
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