Keratin 17 as a therapeutic target for the treatment of psoriasis.

@article{Fu2012Keratin1A,
  title={Keratin 17 as a therapeutic target for the treatment of psoriasis.},
  author={Meng Hsuan Fu and Gang S. Wang},
  journal={Journal of dermatological science},
  year={2012},
  volume={67 3},
  pages={
          161-5
        }
}
Keratin 17 (K17) is the only ectopically expressed keratin in psoriatic lesional epidermis. This review focuses mainly on reports that have addressed the mechanism of K17 up-regulation and its biological role in psoriasis. In addition to IFN-γ, IL-17A and IL-22, which are derived from Th17 and Th22 cells, could up-regulate K17 mRNA and protein levels in keratinocytes in a dose-dependent manner. Moreover, these effects are partially blocked with STAT1- and STAT3-specific inhibitors, as well as… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

Psoriasis as an autoimmune disease

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Psoriasis: A STAT3-Centric View

  • International journal of molecular sciences
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers