KeraSkin-VM: a novel reconstructed human epidermis model for skin irritation tests.

@article{Jung2014KeraSkinVMAN,
  title={KeraSkin-VM: a novel reconstructed human epidermis model for skin irritation tests.},
  author={Kyoung-mi Jung and Su-Hyon Lee and Won-hee Jang and Haeng-Sun Jung and Yong Jun Heo and Young-Ho Park and SeungJin Bae and Kyung-Min Lim and Seung Hyeok Seok},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2014},
  volume={28 5},
  pages={742-50}
}
Several alternative in vitro methods to evaluate skin irritants have been developed recently. In July 2010, OECD officially endorsed the validated reference method (VRM) that uses reconstituted human epidermis (RhE) models as replacements for the in vivo skin irritation test. This study evaluated the KeraSkin-VM model, a novel human epidermis model that was reconstructed with Asian skin tissue using 20 reference chemicals according to the OECD TG 439 performance standard. The test chemicals… CONTINUE READING

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