Keloid-derived fibroblasts have a diminished capacity to produce prostaglandin E2.

@article{Yeh2006KeloidderivedFH,
  title={Keloid-derived fibroblasts have a diminished capacity to produce prostaglandin E2.},
  author={F L Yeh and H D Shen and Ming-Wei Lin and Ching-Yun Chang and Hsiao-Yun Tai and Mei-Hsiang Huang},
  journal={Burns : journal of the International Society for Burn Injuries},
  year={2006},
  volume={32 3},
  pages={299-304}
}
Keloids result from pathological wound healing responses. However, the pathogenesis of keloids is still poorly understood. PGE2 was shown to decrease fibroblast proliferation, inhibit collagen synthesis and enhance the expression of matrix-metalloproteinases (MMPs). This study sought to delineate the production of PGE2 by normal and keloid-derived dermal fibroblasts. Human normal and keloid dermal fibroblasts were cultured in vitro. Cell proliferation and viability were determined based on WST… CONTINUE READING
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