Kelch repeat proteins control yeast PKA activity in response to nutrient availability.

@article{Budhwar2011KelchRP,
  title={Kelch repeat proteins control yeast PKA activity in response to nutrient availability.},
  author={Roli Budhwar and Guoqiang Fang and Jeanne P. Hirsch},
  journal={Cell cycle},
  year={2011},
  volume={10 5},
  pages={767-70}
}
Regulation of protein kinase A (PKA) by binding of cAMP to the regulatory subunit and the resulting release of the active catalytic subunit is a very well established mechanism of kinase activation. We have shown recently that PKA in budding yeast is also subject to an additional level of regulation that that modulates its activity in response to nutrient availability. Nutrient regulation of PKA activity requires a pair of proteins, Gpb1 and Gpb2, that contain several kelch repeats, a sequence… CONTINUE READING