Keeping enhancers under control

@article{Corces1995KeepingEU,
  title={Keeping enhancers under control},
  author={Victor G. Corces},
  journal={Nature},
  year={1995},
  volume={376},
  pages={462-463}
}
  • V. Corces
  • Published 10 August 1995
  • Biology
  • Nature
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The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation.
TLDR
Evidence is provided that the 95-bp mu enhancer core can establish localized factor access in nuclear chromatin independent of detectable transcription by endogenous polymerases and suggest that multiple steps are involved in the alteration of chromatin structure.
DNA position-specific repression of transcription by a Drosophila zinc finger protein.
TLDR
Expression of the yellow (y) gene of Drosophila melanogaster is controlled by a series of tissue-specific transcriptional enhancers located in the 5' region and intron of the gene, and insertion of the gypsy retrotransposon in the y2 allele results in a spatially restricted phenotype.
Modulation of enhancerá¤-promoter interactions by insulators in the Drosophilaembryo
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It is demonstrated that both insulators block the interaction of defined even-skipped (eve) stripe enhancers6,7 when positioned between the enhancer and the target promoter, suggesting that insulators might not be restricted to the functional isolation of neighbouring genetic loci and might function as flexible regulatory elements that modulate enhancer-promoter interactions within complex promoters and complex Genetic loci.