Keeping enhancers under control

  title={Keeping enhancers under control},
  author={Victor G. Corces},
  • V. Corces
  • Published 10 August 1995
  • Biology
  • Nature
Current status of globin gene therapy for the treatment of β‐thalassaemia
Using lentiviral vectors, it has been demonstrated that an optimized combination of proximal and distal transcriptional control elements permits lineage‐specific and elevated β‐globin expression in vivo, resulting in the correction of anaemia and secondary organ damage in β‐thalassaemic mice.
Development of Transformation for Genome Editing of an Emerging Model Organism
Development of transformation for the fungus fly Sciara (Bradysia) coprophila is presented and may serve as a paradigm for development of Transformation for other emerging systems, especially insects.
Transcription in the context of the 3D nucleus.
Quantitation of interactions between two DNA loops demonstrates loop domain insulation in E. coli cells
Modeling shows that combining loop assistance and loop interference can provide strong specificity in long-range interactions in eukaryotic gene regulation.
Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function
The result of recent work that supports the idea that chromatin insulators function as general facilitators of higher-order chromatin loop structures that exert both physical and functional constraints on the genome is summarized.
Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators
It is shown that while loop formation is not in itself sufficient to explain action at a distance, incorporating transient nonspecific and moderate attractive interactions between the chromatin fibers strongly enhances long-distance regulatory interactions and is sufficient to generate a euchromatin-like state.
Interleukin-4 induced leukocyte differentiation
BEAF Regulates Cell-Cycle Genes through the Controlled Deposition of H3K9 Methylation Marks into Its Conserved Dual-Core Binding Sites
The results reveal a novel role for BEAF chromatin dual-cores in regulating a distinct set of genes involved in chromosome organization/segregation and the cell cycle.
Biological Emergences: Evolution by Natural Experiment
In "Biological Emergences", Robert Reid argues that natural selection is not the cause of evolution and proposes an alternative theory to explain how emergent novelties are generated and under what conditions they can overcome the resistance of natural selection.


The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation.
Evidence is provided that the 95-bp mu enhancer core can establish localized factor access in nuclear chromatin independent of detectable transcription by endogenous polymerases and suggest that multiple steps are involved in the alteration of chromatin structure.
DNA position-specific repression of transcription by a Drosophila zinc finger protein.
Expression of the yellow (y) gene of Drosophila melanogaster is controlled by a series of tissue-specific transcriptional enhancers located in the 5' region and intron of the gene, and insertion of the gypsy retrotransposon in the y2 allele results in a spatially restricted phenotype.
Modulation of enhancerá¤-promoter interactions by insulators in the Drosophilaembryo
It is demonstrated that both insulators block the interaction of defined even-skipped (eve) stripe enhancers6,7 when positioned between the enhancer and the target promoter, suggesting that insulators might not be restricted to the functional isolation of neighbouring genetic loci and might function as flexible regulatory elements that modulate enhancer-promoter interactions within complex promoters and complex Genetic loci.