Keeping calcium in its place: Ca(2+)-ATPase and phospholamban.

  title={Keeping calcium in its place: Ca(2+)-ATPase and phospholamban.},
  author={David L. Stokes},
  journal={Current opinion in structural biology},
  volume={7 4},
Electron microscopy is gradually revealing more and more about the structure of the calcium pump from the sarcoplasmic reticulum, Ca(2+)-ATPase. The most recent result reveals the ATP-binding site, and two different avenues are being pursued towards achieving a higher resolution structure. Although no such structures are currently available for phospholamban, various spectroscopies and site-directed mutagenesis have been combined to produce a compelling structural model for its regulation of Ca… CONTINUE READING