Keeping an open mind

@article{Kilcullen2004KeepingAO,
  title={Keeping an open mind},
  author={Rupert John Kilcullen},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={985}
}
There was once considerable scepticism about kinase inhibition as a therapeutic strategy. But, as reflected in this month's focus issue on kinases in cancer, kinases are now the second most important class of drug targets. Could this transition hold general lessons for drug research?