Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.

@article{Visvader2009KeepingAO,
  title={Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.},
  author={Jane E. Visvader},
  journal={Genes & development},
  year={2009},
  volume={23 22},
  pages={2563-77}
}
The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent identification of stem and progenitor populations in mouse and human mammary tissue has provided evidence that the mammary epithelium is organized in a hierarchical manner. Characterization of these normal epithelial subtypes is an important step toward understanding which cells are predisposed to oncogenesis. This… CONTINUE READING
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PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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