Keeping a close eye on Wnt-1/wg signaling in Xenopus

@article{Gradl1999KeepingAC,
  title={Keeping a close eye on Wnt-1/wg signaling in Xenopus},
  author={Dietmar Gradl and Michael K{\"u}hl and Doris Wedlich},
  journal={Mechanisms of Development},
  year={1999},
  volume={86},
  pages={3-15}
}
Nearly two decades have past since description of the ®rst member of the Wnt family by Nusse and Varmus in 1982. Wnt-1 (at that time int-1) was shown to encode a secreted glycoprotein, and misexpression of Wnt-1 was found to promote mammary tumors in mice (Nusse and Varmus, 1982). Tremendous efforts have been undertaken to decipher the intracellular signaling events triggered by this family of extracellular glycoproteins, and now many of the principal mechanisms have been elucidated. Results… CONTINUE READING
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