Keeping a close eye on Wnt-1/wg signaling in Xenopus

  title={Keeping a close eye on Wnt-1/wg signaling in Xenopus},
  author={Dietmar Gradl and Michael K{\"u}hl and Doris Wedlich},
  journal={Mechanisms of Development},
Nearly two decades have past since description of the ®rst member of the Wnt family by Nusse and Varmus in 1982. Wnt-1 (at that time int-1) was shown to encode a secreted glycoprotein, and misexpression of Wnt-1 was found to promote mammary tumors in mice (Nusse and Varmus, 1982). Tremendous efforts have been undertaken to decipher the intracellular signaling events triggered by this family of extracellular glycoproteins, and now many of the principal mechanisms have been elucidated. Results… CONTINUE READING
14 Extracted Citations
126 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 126 references

catenin with the transcription factor LEF-1. Nature

  • J. Behrens, Jerchow, +7 authors W. Birchmeier
  • 1998
Highly Influential
8 Excerpts

A b - catenin / XTcf - 3 complex binds to the siamois promoter to regulate dorsal axis speci ® cation in Xenopus

  • M. Brannon, J. D. Brown, R. Bates, D. Kimelman, R. T. Moon
  • Genes Dev .
  • 1999
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…