Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii.

  title={Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii.},
  author={Ken Wesson and Mark T. Hamann},
  journal={Journal of natural products},
  volume={59 6},
Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones. 
Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.
A macrocylic dodecapeptide was isolated from the sea slug Pleurobranchus forskalii and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 μM.
Ergot alkaloid from the sea slug Pleurobranchus forskalii.
  • T. Wakimoto, K. C. Tan, I. Abe
  • Environmental Science, Chemistry
    Toxicon : official journal of the International Society on Toxinology
  • 2013
Marine molluscs as a potential drug cabinet: an overview
The current status of biologically active compounds extracted, identified and isolated from marine molluscs and tested for their anti- cancer, anti-inflammatory and anti-microbial activities together with important compounds isolated from them such as Dolastatin 10 & 15, Kahalalide F, Keenamide A, Spisulosine-ES-285 etc. which possess anti-cancer and Ziconotide having anti- inflammatory properties are discussed in this paper.
Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects
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This review highlights some of the bioactive peptides that have been obtained from marine molluscs as well the challenges facing bioprospecting of valuable peptides from marinemollusc sources.
Bioactive Compounds from Marine Heterobranchs
Heterobranch molluscs are extremely interesting in regard to the study of marine natural products in terms of both chemical ecology and biotechnology studies, providing many leads for further detailed research in these fields in the near future.
Marine peptide secondary metabolites
Five families of biologically active marine peptides of diverse origin are focused on, ranging from the oldest living cell of the world, the cyanobacteria, to more sophisticated organisms such as tunicates or mollusks, to exemplify the extraordinary chemical diversity within a single organism.
Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals
The immense potential of marine animals as bioactive peptide sources, since they have been found as secondary metabolites from sponges, ascidians, tunicates, and mollusks, is demonstrated.