Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii.

@article{Wesson1996KeenamideAA,
  title={Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii.},
  author={Ken Wesson and Mark T. Hamann},
  journal={Journal of natural products},
  year={1996},
  volume={59 6},
  pages={
          629-31
        }
}
Keenamide A (1), a new cytotoxic cyclic hexapeptide, was isolated from the notaspidean mollusk Pleurobranchus forskalii. Its structure was determined by NMR spectral data interpretation and chiral amino acid analysis. Keenamide A (1) exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones. 
Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii.
TLDR
A macrocylic dodecapeptide was isolated from the sea slug Pleurobranchus forskalii and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 μM.
Ergot alkaloid from the sea slug Pleurobranchus forskalii.
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The current status of biologically active compounds extracted, identified and isolated from marine molluscs and tested for their anti- cancer, anti-inflammatory and anti-microbial activities together with important compounds isolated from them such as Dolastatin 10 & 15, Kahalalide F, Keenamide A, Spisulosine-ES-285 etc. which possess anti-cancer and Ziconotide having anti- inflammatory properties are discussed in this paper.
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