Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.

  title={Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.},
  author={Shohei Murakami and Ritsuko Shimizu and P A Romeo and Masayuki Yamamoto and Hozumi Motohashi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={19 3},
Nrf2 is a major transcriptional activator of cytoprotective genes against oxidative/electrophilic stress, and Keap1 negatively regulates Nrf2. Emerging works have also suggested a role for Nrf2 as a regulator of differentiation in various cells, but the contribution of Nrf2 to the differentiation of hematopoietic stem cells (HSCs) remains elusive. Clarifying this point is important to understand Nrf2 functions in the development and/or resolution of inflammation. Here, we established two… CONTINUE READING
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