Kcnkø: single, cloned potassium leak channels are multi-ion pores.

  title={Kcnk\o: single, cloned potassium leak channels are multi-ion pores.},
  author={Nitza Ilan and Steve A. N. Goldstein},
  journal={Biophysical journal},
  volume={80 1},
KCNKØ was the first clone to show attributes of a leak conductance: voltage-independent potassium currents that develop without delay. Its novel product is predicted to have two nonidentical P domains and four transmembrane segments and to assemble in pairs. Here, the mechanistic basis for leak is examined at the single-channel level. KCNKØ channels open at all voltages in bursts that last for minutes with open probability close to 1. The channels also enter a minutes-long closed state in a… CONTINUE READING

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