Kbot55, purified from Buthus occitanus tunetanus venom, represents the first member of a novel α-KTx subfamily

@article{ElFessiMagouri2016Kbot55PF,
  title={Kbot55, purified from Buthus occitanus tunetanus venom, represents the first member of a novel α-KTx subfamily},
  author={Rym ElFessi-Magouri and Steve Peigneur and Oussema Khamessi and Najet Srairi-Abid and Riadh Kharrat},
  journal={Peptides},
  year={2016},
  volume={80},
  pages={4-8}
}
Kbot55 is a 39 amino acid peptide isolated from the venom of the Tunisian scorpion Buthus occitanus tunetanus. This peptide is cross-linked by 3 disulfide bridges and has a molecular mass of 4128.65Da. Kbot55 is very low represented in the venom and thus represents a challenge for biochemical characterization. In this study, Kbot55 has been subjected to a screening on ion channels expressed in Xenopus laevis oocytes. It was found that Kbot55 targets voltage-gated potassium channels with high… CONTINUE READING

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