Kawasaki disease: novel insights into etiology and genetic susceptibility.

  title={Kawasaki disease: novel insights into etiology and genetic susceptibility.},
  author={Anne H. Rowley},
  journal={Annual review of medicine},
Kawasaki disease (KD) is a vasculitis of young childhood that particularly affects the coronary arteries. Molecular analysis of the oligoclonal IgA response in acute KD led to production of synthetic KD antibodies. These antibodies identify intracytoplasmic inclusion bodies in acute KD tissues. Light and electron microscopic studies indicate that the inclusion bodies are consistent with aggregates of viral proteins and RNA. Advances in molecular genetic analysis and completion of the Human… CONTINUE READING

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