Epidemiology and Risk Factors for Coronary Artery Abnormalities in Children With Complete and Incomplete Kawasaki Disease During a 10-Year Period
Kawasaki disease (KD), an acute febrile mucotaneous lymph node syndrome, was initially described as a distinct clinical entity in 1967 by the Japanese physician, Dr Tomisaku Kawasaki (Kawasaki et al., 1974). Today the disease is recognized as an acute self limited vasculitis of unknown etiology that predominantly affects young children of all racial and ethnic groups (Shulman et al., 1987). It is characterised by prolonged fever unresponsive to antibiotics, a polymorphous skin rash, erythema of the oral mucosa, lips and tongue, erythema of the palms and soles, bilateral conjunctival injection and cervical lymphadenopathy. This disease has become the leading cause of acquired heart disease among children in the developed world, with coronary artery aneurysms occurring in up to 25% of untreated cases (Newburger & Fulton, 2004).