Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation.

@article{Wruck2008KavalactonesPN,
  title={Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation.},
  author={Christoph Jan Wruck and Mario E. G{\"o}tz and Th. Herdegen and Deike J. Varoga and Lars-Ove Brandenburg and Thomas Pufe},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 6},
  pages={
          1785-95
        }
}
One hallmark of Alzheimer's disease is the accumulation of amyloid beta-peptide (AP), which can initiate a cascade of oxidative events that may result in neuronal death. Because nuclear factor erythroid 2-related factor 2 (Nrf2) is the major regulator for a battery of genes encoding detoxifying and antioxidative enzymes via binding to the antioxidant response element (ARE), it is of great interest to find nontoxic activators of Nrf2 rendering neuronal cells more resistant to AP toxicity. Using… CONTINUE READING

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