Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro

  title={Kavalactones Yangonin and Methysticin Induce Apoptosis in Human Hepatocytes (HepG2) In Vitro},
  author={J. Tang and R. Dunlop and A. Rowe and K. Rodgers and I. Ramzan},
  journal={Phytotherapy Research},
  • J. Tang, R. Dunlop, +2 authors I. Ramzan
  • Published 2011
  • Biology, Medicine
  • Phytotherapy Research
  • While cases of severe kava hepatotoxicity have been reported, studies examining the toxicity of individual kavalactones are limited. The present study examined the in vitro hepatotoxicity of kavain, methysticin and yangonin on human hepatocytes (HepG2) and the possible mechanism(s) involved. Cytotoxicity was assessed using lactate dehydrogenase (LDH) and ethidium bromide (EB) assays. The mode of cell death was analysed with acridine orange/ethidium bromide dual staining with fluorescence… CONTINUE READING
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