Kava-induced dermopathy: a niacin deficiency?

  title={Kava-induced dermopathy: a niacin deficiency?},
  author={Patricia Ruze},
  journal={The Lancet},
  • P. Ruze
  • Published 16 June 1990
  • Medicine
  • The Lancet
Kava dermopathy in Fiji: an acquired ichthyosis?
The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3.
Acquired ichthyosis and pityriasis rotunda.
Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells
Water extractable active ingredients may play a role in the physiological and pathophysiological effects of kava, and suggests that mast cell activation may be a mechanistic component of kavalactones‐related skin inflammations.
Kava kava: examining new reports of toxicity.
The ‘Natural Health Service’: natural does not mean safe
In this review, a few commonly known plants with psychotropic effects (St John’s wort, Ginkgo biloba, kava, ginseng and valerian) are discussed by way of illustration.
Toxicity of Kava Kava
The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity.
Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration
A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined.
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
Piper methysticum leaf/root/stem extract is the cosmetic ingredient name for a material derived from the leaves, roots, and stems of the Piper methysticum G. Forster plant, commonly known as kava
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
The available oral toxicity data support the concern about liver damage on ingestion but do not resolve the question, for example, whether these ingredients would be substantially absorbed through the skin, and the available data are insufficient to support the safety of these ingredients in cosmetics.


Pellagra: a still existing disease
Pellagra is no longer the medico-social problem it was in the past but in countries with a low nutritional level it continues to a considerable degree in endemic form and in areas of the so-called 'civilized world' where nutritional problems do not really exist, occasional cases are found.
Cutaneous syndromes produced as side effects of triparanol therapy.
It is shown that dryness of the skin and a picture of pseudoacanthosis nigricans were produced by nicotinic acid administered in large quantities to patients for hypercholesterolemia and it was logical to look for such changes in patients taking a different medication but for a similar purpose, namely, to decrease plasma cholesterol.
Ichthyosis induced by cholesterol-lowering drugs. Implications for epidermal cholesterol homeostasis.
For example, hairless mice fed azacosterol hydrochloride (20,25-diazacholesterol) develop a generalized scaling disorder without loss of barrier function, and topical or systemic repletion with cholesterol can correct the scaling abnormalities.
Nutritional deficiency and the skin.
  • S. Miller
  • Medicine
    Journal of the American Academy of Dermatology
  • 1989
Myotonia and keratoderma induced by 20,25 diazacholestenol.
A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum.
Parameters of Kava Used as a Challenge to Alcohol
  • J. Cawte
  • Psychology
    The Australian and New Zealand journal of psychiatry
  • 1986
At the high level of intake in this community, medical effects hitherto unreported are being observed, and further studies of the clinical effects and the human metabolism of high dosage kava are needed.
Characterization and Physiological Activity of Some Kawa Constituents
Piper metbysticum Forster is a shrub in the family Piperaceae which occurs in Oceania. Its striking characteristics are long-stemmed, heartshaped leaves, peculiarly knotty branches, and small flowers
Effects of the heavy usage of kava on physical health: summary of a pilot survey in an Aboriginal community
There is a strong rationale for urgent social action to improve health in Aboriginal communities and, in particular, to reduce the consumption of kava and to improve the nutritional status of kAVA users.
Some visual effects caused by the beverage kava.