Kava-induced dermopathy: a niacin deficiency?

@article{Ruze1990KavainducedDA,
  title={Kava-induced dermopathy: a niacin deficiency?},
  author={Patricia Ruze},
  journal={The Lancet},
  year={1990},
  volume={335},
  pages={1442-1445}
}
  • P. Ruze
  • Published 16 June 1990
  • Medicine
  • The Lancet
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TLDR
The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3.
Acquired ichthyosis and pityriasis rotunda.
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TLDR
Water extractable active ingredients may play a role in the physiological and pathophysiological effects of kava, and suggests that mast cell activation may be a mechanistic component of kavalactones‐related skin inflammations.
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The ‘Natural Health Service’: natural does not mean safe
TLDR
In this review, a few commonly known plants with psychotropic effects (St John’s wort, Ginkgo biloba, kava, ginseng and valerian) are discussed by way of illustration.
Toxicity of Kava Kava
TLDR
The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity.
Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration
TLDR
A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined.
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
Piper methysticum leaf/root/stem extract is the cosmetic ingredient name for a material derived from the leaves, roots, and stems of the Piper methysticum G. Forster plant, commonly known as kava
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
TLDR
The available oral toxicity data support the concern about liver damage on ingestion but do not resolve the question, for example, whether these ingredients would be substantially absorbed through the skin, and the available data are insufficient to support the safety of these ingredients in cosmetics.
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