Kava-induced dermopathy: a niacin deficiency?

@article{Ruze1990KavainducedDA,
  title={Kava-induced dermopathy: a niacin deficiency?},
  author={P. Ruze},
  journal={The Lancet},
  year={1990},
  volume={335},
  pages={1442-1445}
}
  • P. Ruze
  • Published 1990
  • Medicine
  • The Lancet
Heavy chronic consumption of kava (Piper methysticum) is associated with a pellagroid dermopathy that has been attributed to niacin deficiency. Over 200 male kava drinkers in the Tonga Islands were interviewed and examined regarding the characteristic skin changes. A scaly rash suggestive of ichthyosis and eye irritation were present in some heavy kava drinkers. 29 kava drinkers with prominent skin changes were randomised to receive either 100 mg oral nicotinamide or placebo daily for three… Expand
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62 Citations

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Citation Type

Kava dermopathy in Fiji: an acquired ichthyosis?
TLDR
The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3. Expand
Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern
TLDR
Significant similarity in primary cutaneous lesion morphology and histopathology is described; specifically, edematous papules and plaques tend to plaques on the upper trunk. Expand
Acquired ichthyosis and pityriasis rotunda.
TLDR
The association between AI and underlying malignant processes was initially recognized in the 1940s when Ronchese described AI in association with Hodgkins’s disease and many authors have reported AI in conjunction with various malignancies, chronic diseases, endocrine disorders, connective tissue diseases, malnutrition, medication, and acquired immunodeficiency syndrome (AIDS). Expand
Kava Kava : Gift of the Islands
Piper methysticum, also known as kava kava, is a highly esteemed medicinal herb that has been at the center of social and ceremonial life in the Pacific islands from before the time of written… Expand
Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells
TLDR
Water extractable active ingredients may play a role in the physiological and pathophysiological effects of kava, and suggests that mast cell activation may be a mechanistic component of kavalactones‐related skin inflammations. Expand
Kava kava: examining new reports of toxicity.
Before 1998, extracts of kava kava, Piper methysticum, were considered to be very safe alternatives to anxiolytic drugs and to possibly exert a wide range of other benefits. Major reviews published… Expand
Toxicity of Kava Kava
TLDR
The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity. Expand
The ‘Natural Health Service’: natural does not mean safe
TLDR
In this review, a few commonly known plants with psychotropic effects (St John’s wort, Ginkgo biloba, kava, ginseng and valerian) are discussed by way of illustration. Expand
Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration
TLDR
A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined. Expand
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
TLDR
The available oral toxicity data support the concern about liver damage on ingestion but do not resolve the question, for example, whether these ingredients would be substantially absorbed through the skin, and the available data are insufficient to support the safety of these ingredients in cosmetics. Expand
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