Kava-induced dermopathy: a niacin deficiency?

  title={Kava-induced dermopathy: a niacin deficiency?},
  author={P. Ruze},
  journal={The Lancet},
  • P. Ruze
  • Published 1990
  • Medicine
  • The Lancet
Heavy chronic consumption of kava (Piper methysticum) is associated with a pellagroid dermopathy that has been attributed to niacin deficiency. Over 200 male kava drinkers in the Tonga Islands were interviewed and examined regarding the characteristic skin changes. A scaly rash suggestive of ichthyosis and eye irritation were present in some heavy kava drinkers. 29 kava drinkers with prominent skin changes were randomised to receive either 100 mg oral nicotinamide or placebo daily for three… Expand
Kava dermopathy in Fiji: an acquired ichthyosis?
The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3. Expand
Kava-induced acute cutaneous toxicity: An increasingly recognized characteristic clinicohistologic pattern
Significant similarity in primary cutaneous lesion morphology and histopathology is described; specifically, edematous papules and plaques tend to plaques on the upper trunk. Expand
Acquired ichthyosis and pityriasis rotunda.
The association between AI and underlying malignant processes was initially recognized in the 1940s when Ronchese described AI in association with Hodgkins’s disease and many authors have reported AI in conjunction with various malignancies, chronic diseases, endocrine disorders, connective tissue diseases, malnutrition, medication, and acquired immunodeficiency syndrome (AIDS). Expand
Kava Kava : Gift of the Islands
Piper methysticum, also known as kava kava, is a highly esteemed medicinal herb that has been at the center of social and ceremonial life in the Pacific islands from before the time of writtenExpand
Pacific Island 'Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells
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Kava kava: examining new reports of toxicity.
Before 1998, extracts of kava kava, Piper methysticum, were considered to be very safe alternatives to anxiolytic drugs and to possibly exert a wide range of other benefits. Major reviews publishedExpand
Toxicity of Kava Kava
The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity. Expand
The ‘Natural Health Service’: natural does not mean safe
In this review, a few commonly known plants with psychotropic effects (St John’s wort, Ginkgo biloba, kava, ginseng and valerian) are discussed by way of illustration. Expand
Safety review of kava (Piper methysticum) by the Natural Standard Research Collaboration
A recommendation is made to consolidate and analyse available reports and to continue postmarket surveillance in an international repository to prevent duplicates and promote collection of thorough details at the time of each report so that any association with kava is clearly defined. Expand
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract
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Cutaneous syndromes produced as side effects of triparanol therapy.
It is shown that dryness of the skin and a picture of pseudoacanthosis nigricans were produced by nicotinic acid administered in large quantities to patients for hypercholesterolemia and it was logical to look for such changes in patients taking a different medication but for a similar purpose, namely, to decrease plasma cholesterol. Expand
Ichthyosis induced by cholesterol-lowering drugs. Implications for epidermal cholesterol homeostasis.
For example, hairless mice fed azacosterol hydrochloride (20,25-diazacholesterol) develop a generalized scaling disorder without loss of barrier function, and topical or systemic repletion with cholesterol can correct the scaling abnormalities. Expand
Nutritional deficiency and the skin.
  • S. Miller
  • Medicine
  • Journal of the American Academy of Dermatology
  • 1989
Cutaneous changes occur in deficiency states of many nutritional elements: ascorbic acid, retinol, protein-energy, cyanocobalamin, phytonadione (vitamin K), biotin, ribroflavin, pyridoxine, niacin,Expand
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Parameters of Kava Used as a Challenge to Alcohol
  • J. Cawte
  • Psychology, Medicine
  • The Australian and New Zealand journal of psychiatry
  • 1986
At the high level of intake in this community, medical effects hitherto unreported are being observed, and further studies of the clinical effects and the human metabolism of high dosage kava are needed. Expand
Characterization and Physiological Activity of Some Kawa Constituents
Piper metbysticum Forster is a shrub in the family Piperaceae which occurs in Oceania. Its striking characteristics are long-stemmed, heartshaped leaves, peculiarly knotty branches, and small flowersExpand
Effects of the heavy usage of kava on physical health: summary of a pilot survey in an Aboriginal community
There is a strong rationale for urgent social action to improve health in Aboriginal communities and, in particular, to reduce the consumption of kava and to improve the nutritional status of kAVA users. Expand
Some visual effects caused by the beverage kava.
Kava is a drink produced from the plant Piper methysticum and used as a social and ceremonial beverage on many South Pacific islands and no changes were recorded in visual or stereoacuity or in ocular refractive error. Expand
Effects of kava on neuromuscular transmission and muscle contractility.
It is concluded that kava causes paralysis by mechanisms similar to local anaesthetics. Expand