Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects

@article{Sarris2013KavaFT,
  title={Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects},
  author={Jerome Sarris and Con Stough and Rolf Teschke and Zahra T Wahid and Chad A. Bousman and Greg Murray and Karen Savage and Peter Mouatt and Chee H Ng and Isaac Schweitzer},
  journal={Phytotherapy Research},
  year={2013},
  volume={27}
}
Presently, little is known about a number issues concerning kava (Piper methysticum), including (i) whether kava has any withdrawal or addictive effects; (ii) if genetic polymorphisms of the cytochrome (CYP) P450 2D6 liver enzyme moderates any potential adverse effects; and (iii) if medicinal application of kava has any negative or beneficial effect on sexual function and experience. [...] Key Method The study design was a 6-week, double-blind, randomized controlled trial (n = 75) involving chronic…Expand
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References

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Kava in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study
TLDR
Standardized kava may be a moderately effective short-term option for the treatment of generalized anxiety disorder (GAD), and specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava. Expand
The Kava Anxiety Depression Spectrum Study (KADSS): A randomized, placebo-controlled, cross-over trial using an aqueous extract of Piper methysticum
TLDR
The aqueous Kava preparation produced significant anxiolytic and antidepressant activity and raised no safety concerns at the dose and duration studied, and appears equally effective in cases where anxiety is accompanied by depression. Expand
The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
TLDR
The aqueous Kava preparation produced significant anxiolytic and antidepressant activity and raised no safety concerns at the dose and duration studied, and appears equally effective in cases where anxiety is accompanied by depression. Expand
Kava Anxiety Depression Spectrum Study (KADSS): a mixed methods RCT using an aqueous extract of Piper methysticum.
TLDR
If results reveal that the aqueous kava preparation exerts significant anxiolytic effects and appears safe, potentially beneficial impacts may occur. Expand
Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology
TLDR
The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed, and more studies are required to assess comparative efficacy and safety versus established pharmaceutical comparators. Expand
Kava extract for treating anxiety.
TLDR
The evidence presented implies that kava extract is superior compared with placebo and relatively safe as a treatment option for anxiety, and warrant further and more rigorous investigations into the efficacy and safety of kava Extract. Expand
Kava extract versus placebo for treating anxiety
TLDR
Compared with placebo, kava extract is an effective symptomatic treatment for anxiety although, at present, the size of the effect seems small and the effect lacks robustness and is based on a relatively small sample. Expand
Kava hepatotoxicity--a clinical review.
TLDR
In a few individuals kava may be hepatotoxic due to overdose, prolonged treatment, comedication, and probably triggered by an unacceptable quality of the kava raw material; standardization is now required, minimizing thereby hepatotoxicity risks. Expand
Sexual Side-Effects of Contemporary Antidepressants: Review
The aim of the present study was to review the sexual side-effects of contemporary antidepressants in Australia, comparing the selective serotonin re-uptake inhibitors (SSRIs) with venlafaxine,Expand
Kava kava: examining new reports of toxicity.
Before 1998, extracts of kava kava, Piper methysticum, were considered to be very safe alternatives to anxiolytic drugs and to possibly exert a wide range of other benefits. Major reviews publishedExpand
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