Kava extract versus placebo for treating anxiety

@article{Pittler2003KavaEV,
  title={Kava extract versus placebo for treating anxiety},
  author={Max H. Pittler and Edzard Ernst},
  journal={Cochrane Database of Systematic Reviews},
  year={2003},
  volume={2003}
}
Background Constraints on resources and time often render treatments for anxiety such as psychological interventions impracticable. While synthetic anxiolytic drugs are effective, they are often burdened with adverse events. Other options which are effective and safe are of considerable interest and a welcome addition to the therapeutic repertoire. Objectives To assess the effectiveness and safety as reported in rigorous clinical trials of kava extract compared with placebo for treating… Expand
Kava in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study
TLDR
Standardized kava may be a moderately effective short-term option for the treatment of generalized anxiety disorder (GAD), and specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava. Expand
The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials.
TLDR
Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use and liver toxicity is especially possible if taken longer than 8 weeks. Expand
[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
TLDR
Despite the therapeutic potential of medicinal plants in generalized anxiety disorder, very few controlled trials assessing herbal medicines in generalizedxiety disorder were found and these studies present serious flaw design. Expand
Herbal remedies for anxiety - a systematic review of controlled clinical trials.
  • E. Ernst
  • Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2006
TLDR
It was concluded that there is a lack of rigorous studies in this area and that only kava has been shown beyond reasonable doubt to have anxiolytic effects in humans. Expand
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TLDR
The aqueous Kava preparation produced significant anxiolytic and antidepressant activity and raised no safety concerns at the dose and duration studied, and appears equally effective in cases where anxiety is accompanied by depression. Expand
Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology
TLDR
The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed, and more studies are required to assess comparative efficacy and safety versus established pharmaceutical comparators. Expand
Kava for the Treatment of Generalized Anxiety Disorder RCT: Analysis of Adverse Reactions, Liver Function, Addiction, and Sexual Effects
TLDR
There was a highly significant correlation between ASEX reduction (improved sexual function and performance) and anxiety reduction in the whole sample and kava significantly increased female's sexual drive compared to placebo, with no negative effects seen in males. Expand
Valerian for anxiety disorders.
TLDR
There is insufficient evidence to draw any conclusions about the efficacy or safety of valerian compared with placebo or diazepam for anxiety disorders. Expand
Therapeutic Potential of Kava in the Treatment of Anxiety Disorders
TLDR
Clinical studies have shown that kava and kavalactones are effective in the treatment of anxiety at subclinical and clinical levels, anxiety associated with menopause and anxiety due to various medical conditions, and kava should be used with caution. Expand
Kava kava: examining new reports of toxicity.
Before 1998, extracts of kava kava, Piper methysticum, were considered to be very safe alternatives to anxiolytic drugs and to possibly exert a wide range of other benefits. Major reviews publishedExpand
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